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J Clin Oncol 31(27):33273334 Rini BI et al (2011) Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial

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Blood work including inflammatory markers (CRP, ESR), cytokine panels, and immune cell subsets can provide deeper insight into whether the protocol is modulating the underlying immune dysfunction

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Available in various concentrations, Lidocaine is an amide-type local anesthetic that stabilizes neuronal membranes to inhibit impulse initiation and conduction